Expanding the Scope of Photo-Releasable Modalities to Enable Drug Target Identification & Ligandable Residue Mapping
Time: 9:00 am
day: Conference Day 2
Details:
- Development of oxadiazolines as photo-reactive modalities for small molecule functionalization in complex chemical reactions, allowing the exploration of a larger chemical space
- Pressure testing oxadiazolines for robust target engagement with known inhibitors via chemoproteomics and applications for FBDD screens
- Expanding the chemical toolkit with novel chemistries that provide spatial and temporal controlled modification of tryptophan
- Charactering novel chemistries to profile reactive residues across the proteome
