Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting with Mass Spectrometry Collectively Discriminate the Binding of Small Molecule Therapeutics to Bcl-2
Time: 3:15 pm
day: Conference Day 2
Details:
- OX-MS analysis clearly distinguishes the binding profiles of two drugs to BCL-2 demonstrating its ability to complement HDX-MS in screening candidate compounds during drug discovery and development
- OX-MS provides nuanced insight into the nature of small molecule complexes with proteins through sensitivity to structural changes resulting from both direct binding and allostery
- The precision and ease of implementation of Fenton chemistry mediated OX-MS has the potential to enhance pharmaceutical research and therapeutic development pipelines
