Tyzoon Nomanbhoy

Company: Vicinitas Therapeutics

Job title: Vice President - Chemical Biology

Seminars:

Panel Discussion: Integrating Discovery with Emerging Advances in Proteomics to Create Seamless Workflows that Yield Actionable Insights 11:30 am

How can we complements discovery proteomics with structural data to unravel the “pocketability” of amino acid residues? What are the challenges and innovations in techniques to map protein networks within tissues and how can they complement discovery proteomics? What assays can we use to complement mass spectrometry and obtain comprehensive data on protein-protein interactionsRead more

day: Conference Day 2

Identifying Fragments for Covalent Drug Discovery by Combining Intact Ms Analysis on Recombinant Proteins with Cellular Chemoproteomics Approaches 9:30 am

Discussing the approach of using both intact MS analysis for the high throughput screening of covalent fragments against recombinant proteins, with lower throughput chemoproteomics approaches – in cell competition between compound and desthiobiotin iodoacetamide (DBIA) – to determine target engagement and selectivity against native proteins Evaluating in-cell DBIA results to identify protein degraders and stabilizers…Read more

day: Conference Day 2